Description

Lorcaserin N Carbamoyl Glucuronide is a major, pharmacologically relevant metabolite of the weight management drug Lorcaserin. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics (PK), and bioanalytical method validation. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in metabolism studies, impurity profiling, and the development of reference standards for regulatory submissions.

Application

• Reference Standard for Bioanalysis: Serves as a certified standard for quantifying Lorcaserin and its metabolites in biological matrices (plasma, urine) during clinical and preclinical studies.
• Metabolite Identification & Profiling: Essential for in vitro and in vivo metabolism studies to understand the metabolic pathways and clearance mechanisms of Lorcaserin.
• Impurity Characterization: Used to identify, qualify, and control this specific glucuronidated metabolite as a potential impurity in active pharmaceutical ingredient (API) batches.
• Pharmacokinetic (PK) Research: Enables accurate PK modeling by providing a pure standard to measure the exposure and half-life of this metabolite.
• Regulatory Compliance & Submission: Supports the development of validated analytical methods required for regulatory filings with agencies like the FDA and EMA.
• Stability Studies: Acts as a marker compound in forced degradation and long-term stability studies of Lorcaserin drug products.

Basic Information

Product Name	Lorcaserin N Carbamoyl Glucuronide
CAS No.	1361544-50-4
Molecular Formula	C24H27ClN2O9
Molecular Weight	522.93 g/mol
Synonyms	Lorcaserin N-Carbamoyl Glucuronide; Lorcaserin Carbamoyl Glucuronide; Belviq Metabolite (Carbamoyl Glucuronide); (1R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine N-Carbamoyl-β-D-glucuronide; APD356 N-Carbamoyl Glucuronide; BVT-933 N-Carbamoyl Glucuronide; Lorcaserin M6 Metabolite
EINECS	Contact for details

Quality Control

Our Lorcaserin N Carbamoyl Glucuronide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC purity analysis, NMR and MS for structural confirmation, and residual solvent screening to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time matches reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.