Description

2-{1-[4-(Trifluoromethyl)Phenyl]Cyclobutyl}Acetic Acid is a high-value, synthetically versatile organic building block featuring a cyclobutyl core and a trifluoromethylphenyl moiety. This compound is critical for medicinal chemistry research and pharmaceutical development, offering unique steric and electronic properties for drug candidate optimization. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Scaffold: Used to introduce the cyclobutyl and trifluoromethyl groups, which can improve metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with specific thermal or chemical resistance properties.
• Chemical Biology Probe Development: Employed in the synthesis of tool compounds for studying enzyme mechanisms and protein-ligand interactions.

Basic Information

Product Name	2-{1-[4-(Trifluoromethyl)Phenyl]Cyclobutyl}Acetic Acid
CAS No.	1358805-32-9
Molecular Formula	C13H13F3O2
Molecular Weight	258.24 g/mol
Synonyms	2-[1-[4-(Trifluoromethyl)phenyl]cyclobutyl]acetic acid; 1-[4-(Trifluoromethyl)phenyl]cyclobutane-1-acetic acid; 2-(1-(4-(Trifluoromethyl)phenyl)cyclobutyl)acetic acid; α-(1-(p-(Trifluoromethyl)phenyl)cyclobutyl)acetic acid; 1358805-32-9; Cyclobutanecarboxylic acid, 1-[4-(trifluoromethyl)phenyl]-, homopolymer; (1-(4-(Trifluoromethyl)phenyl)cyclobutyl)acetic acid
EINECS	Contact for details

Quality Control

Our 2-{1-[4-(Trifluoromethyl)Phenyl]Cyclobutyl}Acetic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices for research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.