Description

trans-6-Ethynylpiperidine-3-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique piperidine scaffold bearing ethynyl and nitrile functional groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly for central nervous system (CNS) targets and other specialized drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile reactive handles.
• Chemical Biology Probes: Acts as a precursor for developing molecular probes to study enzyme function and biological pathways.
• Custom Synthesis: Employed in contract research and manufacturing (CRO/CMO) for bespoke chemical synthesis projects.
• Library Synthesis: A valuable component for generating diverse compound libraries for high-throughput screening.

Basic Information

Product Name	trans-6-Ethynylpiperidine-3-Carbonitrile
CAS No.	1357946-90-7
Molecular Formula	C8H10N2
Molecular Weight	134.18 g/mol
Synonyms	6-Ethynyl-3-cyanopiperidine (trans-); (3R,6R)-6-Ethynylpiperidine-3-carbonitrile; (3S,6S)-6-Ethynylpiperidine-3-carbonitrile; trans-6-Ethynyl-3-cyanopiperidine; 3-Cyano-6-ethynylpiperidine; 6-Ethynyl-3-piperidinecarbonitrile; 1357946-90-7; Piperidine-3-carbonitrile, 6-ethynyl-, trans-
EINECS	Contact for details

Quality Control

Our trans-6-Ethynylpiperidine-3-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research and development documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.