Description

Ramiprilat Acyl-β-D-Glucuronide >65% is a key metabolite and reference standard of the active pharmaceutical ingredient ramiprilat, formed via glucuronidation. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics (PK), and bioanalytical method validation. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in advanced analytical chemistry and metabolite identification for cardiovascular drugs.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the qualitative and quantitative analysis of ramiprilat metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Critical for investigating the metabolic pathways, clearance mechanisms, and bioavailability of ramipril and its active form, ramiprilat.
• Bioanalytical Method Development: Serves as a critical standard for developing and validating sensitive HPLC-MS/MS or LC-MS methods for pharmacokinetic studies.
• Impurity Profiling: Employed in the identification and quantification of glucuronide-related impurities or metabolites in active pharmaceutical ingredient (API) batches.
• Regulatory Submissions: Supports Investigational New Drug (IND) and New Drug Application (NDA) filings by providing definitive characterization of major human metabolites.
• In-vitro Metabolism Studies: Used in incubations with hepatocytes or microsomal fractions to study Phase II conjugation reactions specific to ramiprilat.

Basic Information

Product Name	Ramiprilat Acyl-β-D-Glucuronide >65%
CAS No.	1357570-22-9
Molecular Formula	C27H40N2O12
Molecular Weight	584.61 g/mol
Synonyms	Ramiprilat Acyl Glucuronide; Ramiprilat 1-O-β-Acyl Glucuronide; (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid β-D-Glucopyranosiduronic acid ester; Ramiprilat Glucuronide Metabolite; Ramiprilat Acyl-β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Every batch of Ramiprilat Acyl-β-D-Glucuronide >65% is produced and analyzed under strict quality management protocols. The product undergoes rigorous identity confirmation, purity assessment, and impurity profiling using advanced analytical techniques including HPLC, LC-MS, and NMR to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	> 65%
Water Content (KF)	< 5.0 %
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.