Description

Clindamycin-D3 Hydrochloride is a deuterium-labeled isotopologue of the established antibiotic clindamycin hydrochloride, distinguished by the substitution of three hydrogen atoms with deuterium. This high-purity reference standard is critical for ensuring accuracy and reliability in quantitative bioanalytical research and pharmaceutical development. It is primarily utilized by research scientists, analytical laboratories, and pharmaceutical manufacturers engaged in drug metabolism and pharmacokinetics (DMPK) studies, clinical research, and quality control processes.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical, non-interfering reference compound for the precise quantification of clindamycin in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracing and measurement of clindamycin absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used as a key component in establishing robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Facilitates the accurate measurement of clindamycin concentrations in patient samples to optimize dosing regimens and ensure therapeutic efficacy.
• Pharmaceutical Impurity Profiling and Stability Testing: Acts as a reference marker in stability-indicating assays to monitor drug degradation and ensure product shelf-life.
• Forensic and Toxicological Analysis: Supports the definitive identification and quantification of clindamycin in forensic investigations.

Basic Information

Product Name	Clindamycin-D3 Hydrochloride
CAS No.	1356933-72-6
Molecular Formula	C18H30D3ClN2O5S • HCl
Molecular Weight	478.93 g/mol (for monoisotopic mass)
Synonyms	(2S,4R)-N-[(1S,2S)-2-Chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide-d3 hydrochloride; Methyl 7-chloro-6,7,8-trideutero-6,7,8-trideoxy-1-thio-L-threo-α-D-galacto-octopyranoside 2-(dodecyl 2-hydroxy-1-oxobutyl)hydrazinecarboxylate hydrochloride; Clindamycin (D3) hydrochloride; 7-Deoxylincomycin-D3 hydrochloride; Cleocin-D3 HCl
EINECS	Contact for details

Quality Control

Our Clindamycin-D3 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing specifications for identity, purity (by HPLC), isotopic enrichment, and residual solvents. We adhere to relevant industry standards for reference materials, and custom synthesis to meet specific pharmacopeial or client specifications is available.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Keep the container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.