Description

Ramiprilat-D3 is a deuterium-labeled analog of the active metabolite of the antihypertensive drug Ramipril. This high-purity reference standard is critical for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolism studies. Pharmaceutical research and development laboratories rely on this stable isotope-labeled compound for use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) applications to achieve superior precision and minimize matrix effects.

Application

• Primary use as an internal standard in the LC-MS/MS quantification of Ramipril and Ramiprilat in biological matrices (plasma, serum, urine).
• Metabolite profiling and pharmacokinetic studies to understand the absorption, distribution, metabolism, and excretion (ADME) of Ramipril.
• Supporting bioequivalence and clinical trial studies requiring high-sensitivity analytical methods.
• Method development and validation in regulatory-compliant pharmaceutical R&D and quality control laboratories.
• Use in doping control analysis and forensic toxicology for precise identification and quantification.
• Application in stable isotope dilution assays to ensure maximum accuracy in complex sample analysis.

Basic Information

Product Name	Ramiprilat-D3
CAS No.	1356933-70-4
Molecular Formula	C23H29D3N2O5
Molecular Weight	~416.52 g/mol
Synonyms	(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic-3,3,3-d3 acid; Ramiprilat-d3; Ramipril Acid-d3; (S,S,S)-Ramiprilat-d3; Deuterated Ramiprilat; Ramipril-d3 Metabolite; Ramipril D3 Acid; Ramiprilat (Deuterated)
EINECS	Contact for details

Quality Control

Our Ramiprilat-D3 is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, chemical and isotopic purity, and residual solvents. We support regulatory submissions with full traceability and documentation, meeting the stringent requirements of pharmaceutical reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Incorporation)	≥99.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.