Description

Ramipril Benzyl Ester-D5 is a deuterated isotopologue of a key pharmaceutical intermediate used in the synthesis of the angiotensin-converting enzyme (ACE) inhibitor, Ramipril. This high-purity labeled compound is essential for conducting advanced pharmacokinetic, metabolic, and bioanalytical studies, providing critical data for drug development and regulatory submissions. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of reference standards for use in mass spectrometry and other analytical techniques.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard in the quantitative bioanalysis of Ramipril and its metabolites in biological matrices.
• Metabolic Pathway Tracing: Used in drug metabolism and pharmacokinetics (DMPK) studies to elucidate metabolic pathways and identify metabolites.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants during API (Active Pharmaceutical Ingredient) development.
• Stable Isotope Labeled Reference Material: Manufactured as a certified reference standard for calibration and method validation in analytical laboratories.
• Synthetic Intermediate: Employed in the synthesis of deuterated versions of Ramipril for specialized research applications.

Basic Information

Product Name	Ramipril Benzyl Ester-D5
CAS No.	1356929-60-6
Molecular Formula	C23H27D5N2O5
Molecular Weight	~416.52 g/mol
Synonyms	(2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester-D5; Benzyl (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-carbethoxy-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylate-D5; Ramipril Benzyl Ester (pentadeutero); Ramipril Benzyl-d5 Ester; Ramipril Bn Ester-D5
EINECS	Contact for details

Quality Control

Every batch of Ramipril Benzyl Ester-D5 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet the highest standards for research use. Our quality commitment includes comprehensive characterization by NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming batch-specific data for chemical purity, isotopic purity (D-enrichment), and chromatographic profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.