Description

Perindopril-D4 T-Butylamine Salt CAS NO 1356929-59-3 is a high-purity, stable isotope-labeled internal standard essential for accurate quantitative analysis in bioanalytical and pharmacokinetic studies. This deuterated compound is critical for ensuring method specificity and reliability in mass spectrometry-based assays, eliminating matrix effects and variability. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and bioavailability research for cardiovascular therapeutics.

Application

• Internal Standard for LC-MS/MS: Used as a critical reference compound in the quantitative bioanalysis of Perindopril and its metabolites in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and non-clinical studies.
• Method Development and Validation: Serves as a key component in developing and validating robust, regulatory-compliant analytical methods for drug quantification.
• Drug Impurity Profiling and Metabolite Identification: Aids in distinguishing drug-related compounds from endogenous substances in complex samples.
• Quality Control in Pharmaceutical Manufacturing: Supports analytical quality control processes for batch consistency and stability testing of Perindopril API and finished dosage forms.

Basic Information

Product Name	Perindopril-D4 T-Butylamine Salt
CAS No.	1356929-59-3
Molecular Formula	C23H38D4N2O5 • C4H11N
Molecular Weight	~441.64 g/mol (free base)
Synonyms	Perindopril-d4 tert-Butylamine Salt; (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxy-d4)carbonyl]butyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid tert-butylamine salt; Deuterated Perindopril T-Butylamine Salt; Perindopril (ethyl-d4) tert-butylamine salt; Stable Isotope Labeled Perindopril; Perindopril Internal Standard
EINECS	Contact for details

Quality Control

Our Perindopril-D4 T-Butylamine Salt is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for isotopic purity, chemical purity, and identity confirmation via advanced spectroscopic techniques. We adhere to relevant industry guidelines for the production of stable isotope-labeled reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.