Description

Perindopril-D4 CAS NO 1356929-58-2 is a deuterium-labeled analog of the widely prescribed antihypertensive drug Perindopril. This stable isotope-labeled compound is an essential tool in modern pharmaceutical research and development, serving as a critical internal standard for quantitative bioanalytical methods. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in pharmacokinetic studies, drug metabolism research, and ensuring regulatory compliance for bioequivalence testing.

Application

• Internal Standard for LC-MS/MS: Serves as a crucial internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the accurate quantification of Perindopril and its metabolites in biological matrices like plasma and urine.
• Pharmacokinetic and Bioavailability Studies: Enables precise tracking and measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and pre-clinical research.
• Drug Metabolism Research (DMPK): Used to investigate metabolic pathways and identify metabolites, facilitating a deeper understanding of drug behavior in the body.
• Bioanalytical Method Development and Validation: Essential for developing, validating, and transferring robust analytical methods compliant with FDA, EMA, and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Can be employed in advanced QC laboratories to monitor process-related impurities or for method verification.

Basic Information

Product Name	Perindopril-D4
CAS No.	1356929-58-2
Molecular Formula	C19H28D4N2O5•C4H6O4
Molecular Weight	442.52 g/mol (as tert-butylamine salt)
Synonyms	Perindopril-d4; (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-4-(d4)phenyl]butyl]amino]propanoyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt; Deuterated Perindopril; Perindopril (phenyl-d4); Perindopril tert-butylamine-d4 salt; S-9780-d4; Coversyl-d4
EINECS	Contact for details

Quality Control

Our Perindopril-D4 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity, critical for its role as an analytical standard. Each batch is characterized using advanced techniques including NMR, HPLC, and Mass Spectrometry to confirm chemical structure, isotopic enrichment (typically >98% D), and chromatographic purity. A comprehensive Certificate of Analysis (COA) detailing all analytical results is provided with every shipment to support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms to structure
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.