Description

Dihydro Ergotamine-13C,D3 Mesylate is a high-purity, stable isotope-labeled analog of dihydroergotamine, a key ergot alkaloid derivative. This compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, providing unmatched accuracy and reliability for pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on developing and validating LC-MS/MS assays for ergotamine-based therapeutics.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application as a quantitative reference standard in bioanalytical method development and validation for drug metabolism and pharmacokinetics (DMPK) studies.
• Pharmaceutical Research & Development: Used in preclinical and clinical research to ensure accurate quantification of dihydroergotamine and its metabolites in biological matrices like plasma, serum, and tissue homogenates.
• Forensic and Clinical Toxicology: Enables precise measurement of drug levels in forensic analysis and therapeutic drug monitoring (TDM) applications.
• Metabolite Identification and Profiling: Aids in the structural elucidation and tracking of metabolite formation pathways due to its isotopic signature.
• Quality Control in Manufacturing: Supports analytical method transfer and batch release testing in GMP environments for pharmaceutical production.
• Regulatory Submissions: Provides critical data supporting Investigational New Drug (IND) and New Drug Application (NDA) filings with regulatory bodies like the FDA and EMA.

Basic Information

Product Name	Dihydro Ergotamine-13C,D3 Mesylate
CAS No.	1356841-81-0
Molecular Formula	C34H3813CD3N5O5 • CH3SO3H
Molecular Weight	Contact for details
Synonyms	Dihydroergotamine-13C,D3 Mesylate; 9,10-Dihydro-12'-hydroxy-2'-methyl-5'α-(phenylmethyl)ergotaman-3',6',18-trione-13C,D3 Mesylate; DHE-13C,D3 Mesylate; Isotopically Labeled Dihydroergotamine Mesylate; [13C,D3]-Dihydroergotamine Mesylate; (5'α)-9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione-13C,D3 Methanesulfonate; Stable Isotope-Labeled Dihydroergotamine Mesylate Salt
EINECS	Contact for details

Quality Control

Our Dihydro Ergotamine-13C,D3 Mesylate is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for critical analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (e.g., 13C and D atom %), chemical purity by HPLC, and identity confirmation by spectroscopic methods. We adhere to relevant industry standards for reference materials to ensure data integrity and traceability in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom %
Isotopic Enrichment (D)	≥ 98 atom %
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.