Description

(2R, 3'S) Benazepril tert-Butyl Ester D5 is a high-purity, deuterated isotopologue of a key benazepril intermediate. This compound is specifically designed for use in advanced pharmaceutical research and development, offering a stable isotopic label for metabolic and pharmacokinetic studies. It is an essential building block for analytical scientists and process chemists in the pharmaceutical industry who require precise, high-quality materials for method development, synthesis, and regulatory submissions.

Application

• Primary use as a stable isotope-labeled internal standard for the quantitative bioanalysis of benazepril and its metabolites using LC-MS/MS.
• Critical tracer compound in drug metabolism and pharmacokinetics (DMPK) studies to elucidate metabolic pathways.
• Advanced synthetic intermediate in the research-scale preparation of deuterated active pharmaceutical ingredients (APIs).
• Essential reference material for analytical method development and validation in compliance with ICH guidelines.
• Used in impurity profiling and characterization studies for benazepril-based drug substances.
• Supports research in deuterium isotope effect studies to modify the pharmacological properties of drug candidates.

Basic Information

Product Name	(2R, 3'S) Benazepril tert-Butyl Ester D5
CAS No.	1356841-36-5
Molecular Formula	C24H23D5N2O5
Molecular Weight	Approx. 429.52 g/mol
Synonyms	Benazepril tert-Butyl Ester D5; (3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-1-acetic Acid 1,1-Dimethylethyl Ester D5; Deuterated Benazepril tert-Butyl Ester; tert-Butyl (3S)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-2,3-dihydro-1H-indole-2-carboxylate D5; Benazepril-d5 tert-Butyl Ester; Benazepril Impurity D5 tert-Butyl Ester; (2R,3'S)-Benazepril tert-butyl-d9 ester (common vendor listing); Stable Isotope Labeled Benazepril Intermediate.
EINECS	Contact for details

Quality Control

Our (2R, 3'S) Benazepril tert-Butyl Ester D5 is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity confirmation. We adhere to stringent in-house quality standards aligned with the needs of pharmaceutical R&D. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.