Description

Trandolaprilat-Phenyl-D5 CAS NO 1356841-27-4 is a deuterated analog of the active metabolite of the ACE inhibitor Trandolapril. This high-purity, isotopically labeled compound is a critical tool for quantitative bioanalytical research, enabling precise pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in drug development and regulatory compliance.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, non-interfering internal standard for the accurate quantification of Trandolapril and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic (PK) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Metabolite Profiling & Identification: Aids in the structural elucidation and quantification of drug metabolites using mass spectrometry.
• Bioanalytical Method Development & Validation: Essential for developing robust, sensitive, and regulatory-compliant (FDA, EMA) analytical methods.
• Drug-Drug Interaction Studies: Used in assays to investigate potential metabolic interactions between co-administered pharmaceuticals.
• Quality Control in Manufacturing: Can be employed as a reference standard for quality control of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Trandolaprilat-Phenyl-D5
CAS No.	1356841-27-4
Molecular Formula	C22H25D5N2O5
Molecular Weight	407.51 g/mol (approx.)
Synonyms	(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid (Phenyl-D5); Trandolaprilat-d5 (Phenyl ring); Trandolapril metabolite-d5; [Phenyl-D5]Trandolaprilat; Deuterated Trandolaprilat; ACE inhibitor metabolite-d5; Internal Standard for Trandolapril.
EINECS	Contact for details

Quality Control

Our Trandolaprilat-Phenyl-D5 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D (Phenyl ring)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.