Description

Ramiprilat-D5 (Mixture of diastereomers) is a deuterium-labeled internal standard critical for the precise quantification of Ramiprilat in bioanalytical studies. This high-purity compound is essential for ensuring accuracy and reliability in pharmacokinetic and metabolism research, particularly when using mass spectrometry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers involved in cardiovascular drug development and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a deuterated internal standard for the accurate quantification of Ramiprilat in complex biological matrices like plasma and serum.
• Pharmacokinetic (PK) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) for the active metabolite of Ramipril.
• Bioequivalence and Bioavailability Testing: Supports critical studies required for generic drug approval and formulation development.
• Metabolite Profiling and Identification: Aids in the structural elucidation and quantification of Ramipril and its related metabolites.
• Method Development and Validation: Serves as a key reagent in developing and validating robust, GLP-compliant analytical methods.
• Clinical Research: Facilitates therapeutic drug monitoring and clinical trial sample analysis for ACE inhibitor therapies.

Basic Information

Product Name	Ramiprilat-D5 (Mixture of diastereomers)
CAS No.	1356837-92-7
Molecular Formula	C23H27D5N2O5
Molecular Weight	~416.52 g/mol
Synonyms	(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid-d5; Ramiprilat-d5; Ramipril D5 Acid; Deuterated Ramiprilat; Ramiprilat Internal Standard; (S,S,S)-Ramiprilat-d5; Perdeuterated Ramiprilat (mixture)
EINECS	Contact for details

Quality Control

Every batch of Ramiprilat-D5 (Mixture of diastereomers) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure it meets the stringent requirements for use as an internal standard. Our quality commitment includes comprehensive characterization by NMR, MS, and HPLC to confirm identity, chemical purity, and isotopic enrichment. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and method compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms to structure
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.