Description

Daptomycin D5 Trifluoroacetate is a high-purity, isotopically labeled internal standard critical for advanced analytical applications. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control departments requiring precise and traceable measurement of Daptomycin.

Application

• Primary use as an Internal Standard for the accurate quantification of Daptomycin in biological matrices (e.g., plasma, serum) via LC-MS/MS.
• Critical component in Pharmacokinetic (PK) and Bioanalytical Studies to determine drug concentration profiles and metabolic stability.
• Enhances method validation for Regulatory Submissions to agencies like the FDA and EMA, providing essential data integrity.
• Supports Drug Metabolism and Pharmacokinetics (DMPK) research in preclinical and clinical development stages.
• Used in quality control laboratories for Impurity Profiling and Method Development of Daptomycin API and finished drug products.

Basic Information

Product Name	Daptomycin D5 Trifluoroacetate
CAS No.	1356579-56-0
Molecular Formula	C72H101D5N17O26 • C2HF3O2
Molecular Weight	~ 1690.8 g/mol (as salt)
Synonyms	Daptomycin-d5 Trifluoroacetate; Daptomycin (D5) TFA Salt; (3S,6R,9S,12R,15S,18S,21S,24S,27S,30S,33S)-6-[(2S)-2-Aminobutanoyl]-30-[(2R)-2-aminopropanoyl]-12-[(1S)-1-hydroxyethyl]-3,9,15,24,27-pentakis(2-methylpropyl)-21-(naphthalen-1-ylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-18-propanoyl-1λ⁵,2,4,7,10,13,16,19,22,25,28,31-dodecaazacyclotritriacontan-33-yl 2-methylpropanoate-d5 Trifluoroacetate; N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-alanyl-L-2-aminobutyryl-glycyl-D-seryl-L-2-aminobutyrylglycyl-L-3-methyl-L-glutamyl-L-2-aminobutyrylglycine-1-lactone-d5 Trifluoroacetate
EINECS	Contact for details

Quality Control

Our Daptomycin D5 Trifluoroacetate is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing chemical purity, isotopic purity (D5 enrichment), and chromatographic profile via validated HPLC and LC-MS methods. We adhere to relevant GMP and ISO 9001 principles for traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Isotopic Purity (D5 Enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.