Description

Hepcidin 25 (Human) CAS NO 1356390-47-0 is a bioactive peptide hormone that plays a central role in the regulation of systemic iron homeostasis. Its primary function is to inhibit iron absorption in the intestines and iron release from macrophages, making it a critical target for research into iron metabolism disorders. This high-purity peptide is essential for researchers and developers in the pharmaceutical and biotechnology sectors, particularly for applications in metabolic studies, drug discovery, and diagnostic assay development.

Application

• Biomedical Research: Fundamental studies on iron metabolism, anemia of chronic disease, and hereditary hemochromatosis.
• Drug Discovery & Development: Screening for agonists or antagonists of hepcidin activity as potential therapeutics for iron-related disorders.
• Diagnostic Assay Development: Used as a reference standard or calibrator in immunoassays (e.g., ELISA) to measure hepcidin levels in clinical samples.
• Cell Culture & In Vitro Studies: Investigation of cellular iron regulation pathways in hepatocytes, macrophages, and intestinal cells.
• Peptide Chemistry & Conjugation: Serves as a starting material for the synthesis of labeled derivatives (e.g., fluorescent, biotinylated) for advanced research applications.

Basic Information

Product Name	Hepcidin 25 (Human)
CAS No.	1356390-47-0
Molecular Formula	C142H218N44O42S9
Molecular Weight	2789.9 g/mol
Synonyms	HAMP (25-49); Hepcidin-25; Liver-expressed antimicrobial peptide 1; LEAP-1; Hepc25; HEPC; Iron regulatory hormone; Hepcidin antimicrobial peptide; HFE2B; Hepcidin (human); Hepcidin-25 (human); HAMP peptide.
EINECS	Contact for details

Quality Control

Our Hepcidin 25 (Human) is produced under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is subjected to comprehensive analytical testing, including HPLC for purity assessment and Mass Spectrometry for identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, peptide content, and endotoxin levels to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store the lyophilized powder desiccated at -20°C. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Molecular Weight	2789.9 ± 2.0 Da
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.