Description

n-Benzyloxycarbonyl (S)-Lisinopril-D5 Ethyl Methyl Diester CAS NO 1356383-20-4 is a high-purity, deuterium-labeled derivative of a key pharmaceutical intermediate. This compound is specifically designed for use in advanced analytical and research applications where isotopic labeling is required for precise tracking and quantification. It is an essential building block for researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on cardiovascular drug metabolism, pharmacokinetic studies, and the synthesis of isotopically labeled standards for mass spectrometry.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quantification of Lisinopril and its metabolites in complex biological matrices using LC-MS/MS.
• Metabolic Pathway Tracing: Utilized in drug metabolism and pharmacokinetic (DMPK) studies to elucidate the absorption, distribution, metabolism, and excretion (ADME) profile of Lisinopril analogs.
• Internal Standard Synthesis: Acts as a key precursor in the synthesis of stable isotope-labeled internal standards (SIL-IS) for bioanalytical method development and validation, ensuring high accuracy and precision.
• Protease Inhibitor Research: Used in biochemical research as a modified intermediate for studying angiotensin-converting enzyme (ACE) inhibitors and related peptidase mechanisms.
• Process Chemistry & Impurity Profiling: Employed in pharmaceutical manufacturing for method development aimed at identifying and quantifying synthetic impurities and degradants.

Basic Information

Product Name	n-Benzyloxycarbonyl (S)-Lisinopril-D5 Ethyl Methyl Diester
CAS No.	1356383-20-4
Molecular Formula	C30H38D5N3O7
Molecular Weight	~560.7 g/mol
Synonyms	Z-Lisinopril-D5 Ethyl Methyl Diester; (S)-1-[(S)-6-Amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]-pyrrolidine-2-carboxylic Acid, N6-Cbz, Ethyl Methyl Diester, D5; Nα-Cbz-Lys-Pro-D5 Ethyl Methyl Diester; Lisinopril-D5 Cbz Protected Diester; N-Carbobenzoxy-Lisinopril-D5 Ethyl Methyl Ester; 1356383-20-4; Deuterated Lisinopril Cbz-Diester Intermediate
EINECS	Contact for details

Quality Control

This high-value analytical standard is manufactured under strict quality control protocols. Each batch is characterized using advanced spectroscopic and chromatographic techniques to ensure identity, purity, and isotopic enrichment meet exacting research requirements. A comprehensive Certificate of Analysis (COA) is provided, detailing results for assay (HPLC), isotopic purity (NMR/MS), and related substances. Our quality system supports compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, seal under argon or nitrogen. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.