Description

Nafcillin-D5 Sodium Salt is a deuterated isotopologue of the semi-synthetic penicillin antibiotic nafcillin, specifically labeled with five deuterium atoms. This high-purity reference standard is essential for ensuring analytical accuracy and reliability in quantitative research and quality control processes. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, pharmacokinetic studies, and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the precise quantification of nafcillin in complex biological matrices such as plasma, serum, and tissue homogenates.
• Pharmaceutical Metabolism Studies: Used in drug metabolism and pharmacokinetics (DMPK) research to track and quantify the parent drug and its metabolites.
• Bioanalytical Method Development: Enables the development and validation of robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Quality Control & Assurance: Acts as a reference material for the assay and impurity profiling of nafcillin sodium in pharmaceutical quality control laboratories.
• Stability-Indicating Assays: Employed in forced degradation studies to monitor the stability of nafcillin formulations under various stress conditions.
• Clinical Research: Supports therapeutic drug monitoring (TDM) studies in clinical settings to optimize dosing regimens.

Basic Information

Product Name	Nafcillin-D5 Sodium Salt
CAS No.	1356354-25-0
Molecular Formula	C21H17D5N2NaO5S
Molecular Weight	447.49 g/mol (approx.)
Synonyms	(2S,5R,6R)-6-[[(2-Ethoxy-1-naphthoyl)(2H5)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt; Nafcillin-d5 Sodium; Sodium (2S,5R,6R)-6-([(2-ethoxy-1-naphthoyl)(2H5)acetyl]amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; Deuterated Nafcillin Sodium Salt; Nafcillin (phenyl-d5) Sodium Salt
EINECS	Contact for details

Quality Control

Every batch of Nafcillin-D5 Sodium Salt is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use as a certified reference material. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and include detailed results for identity, purity (HPLC), isotopic enrichment, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.