Description

24,32-Bis-o-(tert-Butyldimethylsilyl)-Fk-506-13C, D2 (Major) is a high-purity, isotopically labeled derivative of the potent immunosuppressant Tacrolimus (FK-506), specifically modified with tert-butyldimethylsilyl (TBDMS) protecting groups and stable isotopes (13C and D2). This compound is an essential reference standard and critical intermediate for advanced pharmaceutical research and development. It is primarily used by scientists in pharmaceutical R&D, analytical chemistry, and metabolic studies who require precise tools for method development, quantitative analysis, and tracing metabolic pathways.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the identification, purity assessment, and quantification of related FK-506 analogs and metabolites in analytical methods like HPLC and LC-MS.
• Metabolic Pathway Tracing: The incorporation of 13C and D2 isotopes makes it invaluable for mass spectrometry-based studies to elucidate drug metabolism and pharmacokinetics (DMPK) without radioactive hazards.
• Chemical Synthesis Intermediate: Used as a key, protected building block in the multi-step synthesis of novel immunosuppressant derivatives and prodrugs for research purposes.
• Bioanalytical Method Development: Critical for developing and validating highly sensitive and specific assays for FK-506 and its derivatives in biological matrices.
• Stable Isotope-Labeled Internal Standard: Essential for achieving accurate and precise quantification in bioanalytical applications, correcting for matrix effects and instrument variability.
• Research on Immunosuppression Mechanisms: Supports fundamental research into the molecular mechanisms of calcineurin inhibition and T-cell activation.

Basic Information

Product Name	24,32-Bis-o-(tert-Butyldimethylsilyl)-Fk-506-13C, D2 (Major)
CAS No.	1356352-20-9
Molecular Formula	C46H79D213CNO12Si2 *
Molecular Weight	~ 914.4 g/mol *
Synonyms	24,32-Bis-O-(tert-Butyldimethylsilyl)-Tacrolimus-13C, D2
24,32-Bis-O-TBDMS-FK506-13C, D2
Protected FK-506-13C, D2 Derivative
24,32-Di-O-(tert-Butyldimethylsilyl) Tacrolimus Isotopologue
Stable Isotope-Labeled TBDMS-FK506
FK-506-13C,D2 Bis-TBDMS Ether
Major Isomer of 24,32-Bis-O-(TBDMS)-FK-506-13C,D2
EINECS	Contact for details

* Calculated for the major isotopologue. Contact us for the exact specification.

Quality Control

Every batch of 24,32-Bis-o-(tert-Butyldimethylsilyl)-Fk-506-13C, D2 (Major) is produced and analyzed under strict quality systems. Our products undergo rigorous quality testing using advanced techniques like HPLC, LC-MS, and NMR to ensure identity, purity, and isotopic enrichment meet the stringent requirements for research standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %) *
Isotopic Enrichment (MS)	≥ 98 atom % 13C; ≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.

* Typical purity for research-grade material. Higher purity grades are available upon request.