Description

2-Bromo-6-Iodo-4-(Trifluoromethyl)Anisole, 97% is a high-purity, multi-halogenated anisole derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, iodine, and a trifluoromethyl group on an anisole scaffold, makes it an exceptionally versatile intermediate for constructing complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine and iodine substituents provide distinct reactivity for sequential Suzuki, Stille, or Sonogashira cross-coupling reactions, enabling precise molecular assembly.
• Fluorine Chemistry: The -CF3 group makes it a valuable scaffold for studying structure-activity relationships (SAR) in drug discovery and for introducing lipophilicity.
• Chemical Biology: Employed as a probe or tag in bioconjugation chemistry due to its orthogonal reactivity and potential for radiolabeling via the iodine atom.

Basic Information

Product Name	2-Bromo-6-Iodo-4-(Trifluoromethyl)Anisole, 97%
CAS No.	1356114-55-0
Molecular Formula	C8H5BrF3IO
Molecular Weight	395.93 g/mol
Synonyms	1-Bromo-3-iodo-5-(trifluoromethyl)-2-methoxybenzene; 2-Methoxy-3-bromo-5-iodobenzotrifluoride; 3-Bromo-5-iodo-α,α,α-trifluoro-o-anisole; 2-Bromo-6-iodo-4-(trifluoromethyl)methoxybenzene; Anisole, 2-bromo-6-iodo-4-(trifluoromethyl)-; Benzene, 1-bromo-3-iodo-5-(trifluoromethyl)-2-methoxy-
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-Iodo-4-(Trifluoromethyl)Anisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure the specified purity of 97% (min.) and identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to guarantee consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	97.0% min.
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Solubility	Soluble in common organic solvents (DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.