Description

6-(2,2,2-Trifluoroethyl)Pyridin-3-Ylboronic Acid is a high-value organoboron building block essential for modern synthetic chemistry, particularly in cross-coupling reactions. Its core value lies in enabling the efficient and precise construction of complex molecules containing both pyridine and trifluoroethyl motifs, which are critical for modulating the physicochemical properties of target compounds. This advanced intermediate is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation, where the trifluoroethyl group can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the introduction of fluorine atoms can improve lipophilicity and environmental persistence.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial boronic acid partner for coupling with various aryl or heteroaryl halides to create biaryl and heterobiaryl structures, a fundamental transformation in medicinal and process chemistry.
• Material Science Research: Employed in the development of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where its structure can help fine-tune electronic properties.
• Ligand and Catalyst Development: Acts as a precursor for creating novel bidentate or tridentate ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	6-(2,2,2-Trifluoroethyl)Pyridin-3-Ylboronic Acid
CAS No.	1356109-90-4
Molecular Formula	C7H7BF3NO2
Molecular Weight	204.95 g/mol
Synonyms	3-Pyridineboronic acid, 6-(2,2,2-trifluoroethyl)-; (6-(2,2,2-Trifluoroethyl)pyridin-3-yl)boronic acid; 5-Borono-2-(2,2,2-trifluoroethyl)pyridine; 2-(2,2,2-Trifluoroethyl)-5-pyridineboronic acid; 6-(Trifluoroethyl)-3-pyridinylboronic Acid; Boronic acid, B-[6-(2,2,2-trifluoroethyl)-3-pyridinyl]-; 1356109-90-4
EINECS	Contact for details

Quality Control

Our 6-(2,2,2-Trifluoroethyl)Pyridin-3-Ylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance in sensitive applications like Suzuki-Miyaura cross-coupling. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every lot upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.