Description

Benazepril tert-Butyl Ester D5 is a deuterated isotopologue of a key pharmaceutical intermediate. This compound is specifically designed for use in advanced analytical and research applications where isotopic labeling is required. It is primarily utilized by pharmaceutical R&D laboratories and analytical service providers engaged in method development, metabolism studies, and the synthesis of labeled reference standards.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical, non-interfering reference compound for the precise quantification of benazepril and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Used in pharmacokinetic and drug metabolism studies to track the distribution and biotransformation of the parent drug molecule.
• Synthesis of Deuterated APIs: Acts as a high-purity building block in the preparation of deuterium-labeled active pharmaceutical ingredients (APIs) for research purposes.
• Bioanalytical Method Development: Essential for developing and validating sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Stable Isotope Labeling Studies: Enables research into chemical reaction mechanisms and stability testing under various conditions.

Basic Information

Product Name	Benazepril tert-Butyl Ester D5
CAS No.	1356010-96-2
Molecular Formula	C24H23D5N2O5
Molecular Weight	~429.52 g/mol
Synonyms	(3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic Acid 1,1-Dimethylethyl Ester D5; Benazepril-d5 tert-Butyl Ester; 1H-1-Benzazepine-1-acetic acid, 2,3,4,5-tetrahydro-3-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2-oxo-, 1,1-dimethylethyl ester-d5; Deuterated Benazepril tert-Butyl Ester; tert-Butyl (3S)-3-{[(1S)-1-carbethoxy-3-phenylpropyl]amino}-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetate-d5
EINECS	Contact for details

Quality Control

Our Benazepril tert-Butyl Ester D5 is manufactured under controlled conditions to ensure high isotopic and chemical purity, critical for its role as an analytical standard. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, isotopic enrichment (D5), and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.