Description

2-Ethoxy-1-Fluoro-4-(Trifluoromethoxy)Benzene is a high-purity fluorinated aromatic ether building block of significant interest in advanced chemical synthesis. Its unique structure, featuring both ethoxy and trifluoromethoxy substituents on a fluorinated benzene ring, makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the development of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, altering their surface properties, chemical resistance, and durability.
• Organic Synthesis & Catalysis: Acts as a versatile reagent in cross-coupling reactions and as a ligand precursor in organometallic catalysis due to its electron-withdrawing substituents.

Basic Information

Product Name	2-Ethoxy-1-Fluoro-4-(Trifluoromethoxy)Benzene
CAS No.	1355247-03-8
Molecular Formula	C9H8F4O2
Molecular Weight	224.15 g/mol
Synonyms	1-Ethoxy-2-fluoro-4-(trifluoromethoxy)benzene; 2-Fluoro-1-ethoxy-4-(trifluoromethoxy)benzene; 4-Ethoxy-3-fluoro-1-(trifluoromethoxy)benzene; Benzene, 2-ethoxy-1-fluoro-4-(trifluoromethoxy)-; 2-Fluoro-4-(trifluoromethoxy)phenetole
EINECS	Contact for details

Quality Control

Our 2-Ethoxy-1-Fluoro-4-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to guarantee batch-to-batch consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider using an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.