Description

Alkyne-PEG8-CH2CH2COOtBu is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal alkyne group and a protected carboxylic acid. This bifunctional linker is engineered for precision in bioconjugation and materials science, offering controlled reactivity and enhanced solubility. It is primarily utilized by researchers and manufacturers in pharmaceutical development, advanced material synthesis, and proteomics for creating stable, well-defined molecular constructs.

Application

• Bioconjugation and Click Chemistry: Serves as a key linker for coupling biomolecules (peptides, antibodies, oligonucleotides) to surfaces, dyes, or other polymers via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• ADC (Antibody-Drug Conjugate) Development: Used as a spacer arm to connect cytotoxic payloads to monoclonal antibodies, improving solubility and pharmacokinetic profiles.
• PEGylation Reagent: Facilitates the site-specific modification of proteins and peptides to enhance stability, reduce immunogenicity, and prolong circulation half-life.
• Polymer and Hydrogel Synthesis: Acts as a functional monomer or cross-linker for creating smart materials with tailored properties for drug delivery and tissue engineering.
• Probe and Diagnostic Reagent Synthesis: Enables the labeling of biomolecules with imaging agents (e.g., fluorescent dyes) for diagnostic assays and cellular imaging.
• Surface Functionalization: Used to modify nanoparticles, chips, and other solid supports with alkyne groups for subsequent bio-immobilization.

Basic Information

Product Name	Alkyne-PEG8-CH2CH2COOtBu
CAS No.	1355197-91-9
Molecular Formula	C31H58O12
Molecular Weight	622.8 g/mol
Synonyms	t-Butyl 3,6,9,12,15,18,21,24-octaoxa-27-azahentriacont-30-yn-31-oate; Propargyl-PEG8-CH2CH2COOtBu; Alkyne-PEG8-t-butyl ester; 2,5,8,11,14,17,20,23-Octaoxapentacosan-25-ynoic acid, 26-(1,1-dimethylethyl) ester; 1-Propargyl-3,6,9,12,15,18,21,24-octaoxa-27-azahentriacontan-31-oic acid t-butyl ester; Alkyne-PEG8-acid t-butyl ester; t-Butyl-PEG8-propargyl ester; Propargyl-PEG8-COOtBu
EINECS	Contact for details

Quality Control

Our Alkyne-PEG8-CH2CH2COOtBu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided to guarantee the material meets the high standards required for research and cGMP manufacturing. Documentation supports compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive); desiccate upon opening and keep under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.