Description

Propargyl-Peg4-T-Butyl Ester is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal propargyl group and a tert-butyl ester. This compound is a critical intermediate in bioconjugation and click chemistry applications, enabling the precise, covalent attachment of molecules under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science who require reliable, well-characterized building blocks for creating targeted drug conjugates, diagnostic probes, and functional polymers.

Application

• Bioconjugation & Click Chemistry: Serves as a key linker for attaching drugs, dyes, or other functional moieties to biomolecules (e.g., antibodies, proteins, peptides) via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• ADC (Antibody-Drug Conjugate) Development: Used in the synthesis of linker-payload constructs for creating next-generation targeted cancer therapies.
• Proteomics & Biomarker Research: Facilitates the labeling and enrichment of proteins for mass spectrometry analysis and cellular imaging studies.
• Polymer & Material Science: Acts as a functional monomer or cross-linker for synthesizing smart hydrogels, surface coatings, and drug delivery systems with tailored properties.
• Diagnostic Reagent Synthesis: Employed in the production of contrast agents and fluorescent probes for in vitro and in vivo diagnostics.
• Life Science Tool Development: Integrated into kits and reagents for cell biology, genomics, and biochemical assays requiring specific molecular tagging.

Basic Information

Product Name	Propargyl-Peg4-T-Butyl Ester
CAS No.	1355197-66-8
Molecular Formula	C21H38O8
Molecular Weight	418.52 g/mol
Synonyms	Propargyl-PEG4-t-butyl ester; 2,5,8,11-Tetraoxatetradec-13-ynoic acid, 14-tert-butyl ester; Propargyl-PEG4-OtBu; tert-Butyl 3,6,9,12-tetraoxapentadec-14-ynoate; Propargyl tetraethylene glycol mono-tert-butyl ether ester; 3,6,9,12-Tetraoxapentadec-14-ynoic acid, tert-butyl ester; Propargyl-PEG4-tBu ester; Alkyne-PEG4-t-butyl ester
EINECS	Contact for details

Quality Control

Every batch of Propargyl-Peg4-T-Butyl Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment supports applications in GMP-compatible synthesis and critical research, where traceability and reliability are paramount.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.