Description

2-(2,6-Difluoro-4-(Methylthio)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 1355011-25-4 is a high-purity, advanced pharmaceutical intermediate belonging to the class of pinacol boronic esters. This compound is a critical building block in modern synthetic organic chemistry, enabling efficient carbon-carbon bond formation. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing biaryl structures, a common motif in drug discovery and material science.
• Pharmaceutical Intermediate: Serves as a versatile precursor in the synthesis of complex molecules for potential therapeutic agents.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology Probes: Acts as a handle for bioconjugation and labeling in probe development.
• Process Chemistry & Scale-Up: Suitable for optimization and pilot-scale synthesis in industrial manufacturing processes.

Basic Information

Product Name	2-(2,6-Difluoro-4-(Methylthio)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1355011-25-4
Molecular Formula	C₁₃H₁₇BF₂O₂S
Molecular Weight	300.15 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-[2,6-difluoro-4-(methylsulfanyl)phenyl]-1,3,2-dioxaborolane; 2,6-Difluoro-4-(methylthio)benzeneboronic acid pinacol ester; 2-(2,6-Difluoro-4-(Methylmercapto)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane; 2,6-Difluoro-4-(methylthio)phenylboronic acid pinacol ester; Pinacol [2,6-difluoro-4-(methylthio)phenyl]boronate
EINECS	Contact for details

Quality Control

Our production of 2-(2,6-Difluoro-4-(Methylthio)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the rigorous standards required for cGMP and advanced pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.