Description

(3S)-3-Amino-3-(2,4-Difluorophenyl)Propanoic Acid Hydrochloride is a high-purity, non-natural amino acid derivative of significant interest in advanced pharmaceutical research and development. This chiral building block is critical for the synthesis of complex molecules, particularly in the creation of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors seeking to incorporate a specific, fluorinated phenylalanine analog into their molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of new drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Peptide Modification: Used to introduce a difluorophenyl moiety into peptide chains, enhancing metabolic stability, lipophilicity, and binding affinity in therapeutic peptides.
• Protease Inhibitor Development: Serves as a core structural component in the design of inhibitors for various proteolytic enzymes.
• Chemical Biology Probes: Employed in the creation of labeled or modified amino acids for studying protein function and interactions.
• Asymmetric Synthesis: Acts as a valuable starting material or auxiliary in stereoselective synthetic routes due to its defined (S)-configuration.
• API Process Development: Used in scaling up and optimizing manufacturing processes for clinical trial material and commercial API production.

Basic Information

Product Name	(3S)-3-Amino-3-(2,4-Difluorophenyl)Propanoic Acid Hydrochloride
CAS No.	1354970-73-2
Molecular Formula	C9H8F2NO2·HCl
Molecular Weight	239.62 (Free base: 201.16)
Synonyms	(S)-3-Amino-3-(2,4-difluorophenyl)propanoic acid hydrochloride; D-2,4-Difluorophenylalanine hydrochloride (ambiguous, verify stereochemistry); (3S)-3-Amino-3-(2,4-difluorophenyl)propionic acid HCl; 2,4-Difluoro-D-homophenylalanine hydrochloride; (S)-2-Amino-3-(2,4-difluorophenyl)propanoic acid hydrochloride; 3-Amino-3-(2,4-difluorophenyl)propanoic acid hydrochloride (S-isomer); (S)-3-(2,4-Difluorophenyl)-β-alanine hydrochloride
EINECS	Contact for details

Quality Control

Our (3S)-3-Amino-3-(2,4-Difluorophenyl)Propanoic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.