Description

3-Aminotetrahydrofuran-3-Carbonitrile Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique fused-ring structure with both amine and nitrile functionalities. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile chiral building block for medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Protease Inhibitor Synthesis: Used in the construction of core scaffolds for inhibitors targeting various viral and metabolic proteases.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce chiral centers into complex molecules.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds or probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	3-Aminotetrahydrofuran-3-Carbonitrile Hydrochloride
CAS No.	1354963-38-4
Molecular Formula	C6H9N2O·HCl
Molecular Weight	160.61 g/mol (Free base: 125.15 g/mol)
Synonyms	3-Aminooxolane-3-carbonitrile hydrochloride; 3-Aminotetrahydro-3-furancarbonitrile hydrochloride; 3-Cyano-3-aminotetrahydrofuran hydrochloride; 3-Amino-3-cyanotetrahydrofuran HCl; Tetrahydro-3-furancarbonitrile, 3-amino-, hydrochloride; 3-Aminotetrahydrofuran-3-carbonitrile HCl
EINECS	Contact for details

Quality Control

Our 3-Aminotetrahydrofuran-3-Carbonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.