Description

5-Chloro-2,4-Difluoro-n-(Methylsulfonyl)Benzamide is a high-purity, advanced pharmaceutical intermediate characterized by its distinct benzamide core functionalized with halogen and sulfonyl groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly in areas requiring sophisticated fluorinated and chlorinated aromatic systems.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the difluoro and chloro substituents contribute to biological efficacy and environmental stability.
• Material Science Research: Serves as a monomer or functional additive in the development of specialty polymers and advanced organic materials with specific electronic or thermal properties.
• Chemical Biology & Proteomics: Employed as a chemical probe or a scaffold for designing enzyme inhibitors and other bioactive tools due to its sulfonamide moiety.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up processes.

Basic Information

Product Name	5-Chloro-2,4-Difluoro-n-(Methylsulfonyl)Benzamide
CAS No.	1354960-67-0
Molecular Formula	C8H6ClF2NO3S
Molecular Weight	269.65 g/mol
Synonyms	5-Chloro-2,4-difluoro-N-(methylsulfonyl)benzamide; N-(Methylsulfonyl)-5-chloro-2,4-difluorobenzamide; 2,4-Difluoro-5-chloro-N-(methanesulfonyl)benzamide; Benzamide, 5-chloro-2,4-difluoro-N-(methylsulfonyl)-; 1354960-67-0; 5-Chloro-2,4-difluorobenzenesulfonamide derivative
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,4-Difluoro-n-(Methylsulfonyl)Benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.