Description

2-Hydroxy-5-(Trifluoromethoxy)Phenylboronic Acid is a specialized organoboron compound featuring a phenolic hydroxyl group and a trifluoromethoxy substituent, making it a versatile building block for modern synthetic chemistry. This compound is valued for its role in facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries to synthesize novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethoxy-phenyl moiety for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the boronic acid group enables efficient coupling to construct complex heterocyclic systems.
• Ligand & Catalyst Development: Serves as a precursor for designing novel ligands and catalysts in transition metal catalysis and materials science.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, via polymerization or functionalization reactions.
• Chemical Biology Probes: Useful in bioconjugation and the synthesis of molecular probes for studying biological processes.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Hydroxy-5-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	1354819-26-3
Molecular Formula	C7H6BF3O4
Molecular Weight	221.93 g/mol
Synonyms	[2-Hydroxy-5-(trifluoromethoxy)phenyl]boronic acid; 5-(Trifluoromethoxy)-2-hydroxybenzeneboronic acid; 2-Borono-4-(trifluoromethoxy)phenol; (2-Hydroxy-5-(trifluoromethoxy)phenyl)boronic acid; 2-Hydroxy-5-trifluoromethoxybenzeneboronic acid; 2-Hydroxy-5-(trifluoromethoxy)benzeneboronic acid; 1354819-26-3
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxy-5-(Trifluoromethoxy)Phenylboronic Acid undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive coupling reactions. Our quality assurance protocols are designed to guarantee batch-to-batch consistency and reliability. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.