Description

3-(Difluoromethyl)Azetidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine ring system functionalized with a difluoromethyl group. This compound is valued for its role as a critical building block in modern medicinal chemistry, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within oncology, neurology, and anti-infective drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in active pharmaceutical ingredient (API) research and development.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce fluorine atoms for improved drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of bifunctional degraders.
• Agrochemical Research: Employed in the synthesis of novel crop protection agents and pesticides.
• Chemical Biology: Utilized as a probe or tool compound for studying biological targets and pathways.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke chemical synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	3-(Difluoromethyl)Azetidine Hydrochloride
CAS No.	1354792-76-9
Molecular Formula	C4H8ClF2N
Molecular Weight	143.56 g/mol
Synonyms	3-(Difluoromethyl)azetidine hydrochloride; Azetidine, 3-(difluoromethyl)-, hydrochloride (1:1); 3-(Difluoromethyl)azetidine HCl; 1354792-76-9; 3-Difluoromethyl-azetidine hydrochloride; 3-(Difluoromethyl)azetidine monohydrochloride
EINECS	Contact for details

Quality Control

Every batch of 3-(Difluoromethyl)Azetidine Hydrochloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.