Description

tert-Butyl 3-(Difluoromethyl)Azetidine-1-Carboxylate is a high-value, protected azetidine derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its primary commercial value lies in its role as a versatile building block for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and process chemists developing new active ingredients, where the azetidine and difluoromethyl motifs are key pharmacophores.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced crop protection agents, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Chemical Biology Probe Development: Employed in the construction of molecular probes and tool compounds for studying biological pathways and target engagement.
• Ligand and Catalyst Precursor: Serves as a precursor for chiral ligands or catalysts used in asymmetric synthesis, leveraging the stereogenic center of the azetidine ring.
• Material Science Research: Potential monomer or precursor for specialty polymers with unique properties derived from the rigid azetidine scaffold.

Basic Information

Product Name	tert-Butyl 3-(Difluoromethyl)Azetidine-1-Carboxylate
CAS No.	1354792-75-8
Molecular Formula	C9H15F2NO2
Molecular Weight	207.22 g/mol
Synonyms	1-Boc-3-(difluoromethyl)azetidine; 3-(Difluoromethyl)azetidine-1-carboxylic acid tert-butyl ester; tert-Butyl 3-(difluoromethyl)azetidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-(difluoromethyl)azetidine; Azetidine-1-carboxylic acid, 3-(difluoromethyl)-, 1,1-dimethylethyl ester; Boc-3-(difluoromethyl)azetidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Difluoromethyl)Azetidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) documenting batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.