Description

Fmoc-Ser(o-Propargyl)-Oh is a specialized, orthogonally protected serine derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters for its unique propargyl-protected side chain, which enables site-specific chemical modifications via click chemistry, a critical tool for creating peptide-drug conjugates, bioconjugates, and labeled probes. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in developing novel therapeutic peptides, diagnostic tools, and materials science applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): Used as a key building block for the incorporation of serine residues with a protected, modifiable side chain into peptide chains.
• Click Chemistry Conjugation: The propargyl group facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) for the precise attachment of fluorophores, biotin, polyethylene glycol (PEG) chains, or other functional molecules.
• Peptide-Drug Conjugate (PDC) Development: Enables the site-specific linkage of cytotoxic payloads or other therapeutic agents to targeting peptides.
• Bioconjugation and Probe Labeling: Essential for creating labeled peptides for imaging (e.g., fluorescence, PET), diagnostic assays, and studying protein-protein interactions.
• Materials Science and Surface Functionalization: Used to modify surfaces or polymers with bioactive peptide sequences for tissue engineering or biosensor applications.
• Combinatorial Chemistry Libraries: Serves as a versatile monomer for generating libraries of modified peptides for high-throughput screening.

Basic Information

Product Name	Fmoc-Ser(o-Propargyl)-Oh
CAS No.	1354752-75-2
Molecular Formula	C₂₂H₂₁NO₅
Molecular Weight	379.41 g/mol
Synonyms	Fmoc-Ser(Propargyl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-propyn-1-yl)-L-serine; Fmoc-O-propargyl-L-serine; Fmoc-L-serine(O-propargyl); (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-(prop-2-yn-1-yloxy)propanoic acid; Fmoc-Ser(Op)-OH; Fmoc-Ser(O-Pg)-OH; Fmoc-Ser(O-propargyl)
EINECS	Contact for details

Quality Control

Our Fmoc-Ser(o-Propargyl)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.