Description

Fmoc-L-Thyronine CAS NO 1354485-04-3 is a protected derivative of the thyroid hormone thyronine, specifically designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for researchers and manufacturers developing peptide-based pharmaceuticals and biochemical tools. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for the synthesis of complex peptides and hormone analogs, where precise control over amino acid incorporation is essential.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a key intermediate for the automated, stepwise construction of peptide chains.
• Pharmaceutical Research: Used in the development and production of novel peptide therapeutics, particularly those targeting metabolic and endocrine pathways.
• Bioconjugation & Probe Development: Enables the site-specific introduction of thyronine moieties into larger biomolecules for diagnostic or targeting applications.
• Biochemical Research: Employed in studies of thyroid hormone action, receptor binding, and metabolic function at the molecular level.
• Custom Peptide Services: A vital raw material for CROs and CDMOs offering bespoke peptide synthesis for client projects.

Basic Information

Product Name	Fmoc-L-Thyronine
CAS No.	1354485-04-3
Molecular Formula	C30H25NO7
Molecular Weight	511.52 g/mol
Synonyms	Fmoc-Thyronine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-thyronine; Fmoc-T4; Fmoc-O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-tyrosine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid; Fmoc-3,3',5-Triiodo-L-thyronine derivative; Fmoc-L-T4-OH; N-Fmoc-3,5,3'-triiodothyronine
EINECS	Contact for details

Quality Control

Our Fmoc-L-Thyronine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.