Description

4-((R)-Pyrrolidin-3-Ylaminomethyl)-Benzonitrile Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. This compound is valued for its role in the synthesis of complex molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel therapeutic agents, especially in the areas of central nervous system (CNS) and metabolic disorder treatments.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug candidates.
• Ligand Synthesis: Serves as a precursor for the preparation of specialized ligands in catalysis and chemical biology.
• Asymmetric Synthesis: Utilized in the construction of complex, enantiomerically pure molecules due to its defined (R)-configuration.
• Bioconjugation Chemistry: The benzonitrile and amine functional groups offer handles for further chemical modification and bioconjugation strategies.
• Academic & Industrial R&D: A valuable reagent for exploratory synthetic chemistry in both academic and industrial settings.

Basic Information

Product Name	4-((R)-Pyrrolidin-3-Ylaminomethyl)-Benzonitrile Hydrochloride
CAS No.	1354018-48-6
Molecular Formula	C13H18N3•HCl
Molecular Weight	251.76 g/mol (Free base: 215.30 g/mol)
Synonyms	(R)-4-((3-Aminopyrrolidin-1-yl)methyl)benzonitrile hydrochloride; 4-[[(3R)-3-Aminopyrrolidin-1-yl]methyl]benzonitrile hydrochloride; (R)-4-(Pyrrolidin-3-ylaminomethyl)benzonitrile HCl; 4-((R)-3-Aminopyrrolidine-1-ylmethyl)benzonitrile hydrochloride; Benzonitrile, 4-[[(3R)-3-amino-1-pyrrolidinyl]methyl]-, hydrochloride; (R)-4-((3-Aminopyrrolidin-1-yl)methyl)benzonitrile monohydrochloride
EINECS	Contact for details

Quality Control

Our 4-((R)-Pyrrolidin-3-Ylaminomethyl)-Benzonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and development grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee reproducible results for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.