Description

(S)-3-(6-Methoxy-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester CAS NO 1354010-22-2 is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is of significant value for its role in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), especially for therapeutic areas requiring stereochemical precision.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with potential therapeutic benefits.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes for preclinical and clinical trial material production.
• Asymmetric Synthesis: Utilized in the construction of complex molecules where the (S)-configured pyrrolidine moiety is essential for biological activity.
• Contract Manufacturing & Development (CDMO): Supplied to CDMOs for the custom synthesis of client-specific target molecules under cGMP or non-GMP conditions.
• Academic Research: Employed in university and institutional labs for fundamental studies in organic synthesis and chemical biology.

Basic Information

Product Name	(S)-3-(6-Methoxy-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1354010-22-2
Molecular Formula	C14H22N4O3
Molecular Weight	294.35 g/mol
Synonyms	tert-Butyl (3S)-3-[(6-methoxypyrimidin-4-yl)amino]pyrrolidine-1-carboxylate; (S)-tert-Butyl 3-((6-methoxypyrimidin-4-yl)amino)pyrrolidine-1-carboxylate; (S)-1-Boc-3-((6-methoxypyrimidin-4-yl)amino)pyrrolidine; (S)-3-((6-Methoxypyrimidin-4-yl)amino)pyrrolidine-1-carboxylic acid tert-butyl ester; BOC-(S)-3-((6-Methoxypyrimidin-4-yl)amino)pyrrolidine; (S)-3-(6-Methoxy-4-pyrimidinylamino)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We offer material suitable for research and development under non-GMP conditions, with the capability to supply material manufactured under cGMP guidelines for advanced pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.