Description

(S)-3-[(3-Methyl-Thiophene-2-Carbonyl)-Amino]-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) requiring specific stereochemistry. It is primarily utilized by pharmaceutical R&D and manufacturing organizations engaged in the development of novel therapeutics, particularly in areas such as protease inhibitors and other small molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting viral proteases and neurological disorders.
• API Development: Serves as a critical precursor in the research and scale-up production of new chemical entities (NCEs) with defined (S)-configuration.
• Peptidomimetic Research: Used in the design and construction of peptidomimetic compounds where the pyrrolidine scaffold is essential for biological activity.
• Asymmetric Synthesis: Employed in medicinal chemistry for introducing stereocenters and constructing molecular complexity in a controlled manner.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials and commercial APIs.
• Academic & Biotech R&D: Used in university and biotech research labs for exploratory synthesis and structure-activity relationship (SAR) studies.

Basic Information

Product Name	(S)-3-[(3-Methyl-Thiophene-2-Carbonyl)-Amino]-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1354010-01-7
Molecular Formula	C16H24N2O3S
Molecular Weight	324.44 g/mol
Synonyms	(S)-1-Boc-3-[(3-methylthiophene-2-carbonyl)amino]pyrrolidine; (S)-tert-Butyl 3-((3-methylthiophene-2-carboxamido)pyrrolidine-1-carboxylate; (S)-3-[(3-Methyl-2-thiophenecarbonyl)amino]-1-(tert-butoxycarbonyl)pyrrolidine; 1-Boc-3-[(3-methyl-2-thienyl)carbonyl]amino-(S)-pyrrolidine; (S)-1-N-Boc-3-amino-N-(3-methyl-2-thienylcarbonyl)pyrrolidine; (S)-3-Amino-1-Boc-pyrrolidine-3-(3-methyl-2-thiophenecarboxamide); BOC-(S)-3-ATPC; (S)-3-ATPC-Boc
EINECS	Contact for details

Quality Control

Our production of (S)-3-[(3-Methyl-Thiophene-2-Carbonyl)-Amino]-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management systems. The material is manufactured under controlled conditions and undergoes comprehensive analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each batch and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.