Description

2-{[(Piperidin-3-Ylmethyl)-Amino]-Methyl}-Benzonitrile Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined molecular structure. This compound matters for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and receptor-based pathways. Pharmaceutical R&D teams and fine chemical manufacturers need this material to ensure the integrity and scalability of their synthetic routes, enabling the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially in central nervous system (CNS) and GPCR-targeted therapies.
• Organic Synthesis Building Block: Utilized in research and development for constructing complex nitrogen-containing heterocycles and benzonitrile derivatives.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP production of APIs at clinical and commercial scales.
• Biochemical Research: May be used in the development of enzyme inhibitors or receptor ligands for biochemical assays.

Basic Information

Product Name	2-{[(Piperidin-3-Ylmethyl)-Amino]-Methyl}-Benzonitrile Hydrochloride
CAS No.	1353946-10-7
Molecular Formula	C15H21N3·HCl
Molecular Weight	279.81 g/mol (Free base: 243.35 g/mol)
Synonyms	2-(((3-Piperidinylmethyl)amino)methyl)benzonitrile hydrochloride; 2-{[(Piperidin-3-Ylmethyl)-Amino]-Methyl}-Benzonitrile HCl; 2-(((Piperidin-3-ylmethyl)amino)methyl)benzonitrile monohydrochloride; 2-[(Piperidin-3-ylmethylamino)methyl]benzonitrile hydrochloride; Benzonitrile, 2-[[[(3-piperidinyl)methyl]amino]methyl]-, hydrochloride; CAS 1353946-10-7
EINECS	Contact for details

Quality Control

Our 2-{[(Piperidin-3-Ylmethyl)-Amino]-Methyl}-Benzonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.