Description

Firocoxib-D6 is a deuterium-labeled analog of the non-steroidal anti-inflammatory drug (NSAID) firocoxib, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring the accuracy, precision, and reliability of mass spectrometry-based analyses in pharmaceutical research and development. It is primarily utilized by analytical chemists and researchers in pharmaceutical companies, contract research organizations (CROs), and regulatory testing laboratories for pharmacokinetic studies, drug metabolism research, and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of firocoxib in complex biological matrices such as plasma, serum, and tissue homogenates using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Drug Metabolism Research: Used in metabolite identification and profiling studies to understand the biotransformation pathways of firocoxib.
• Veterinary Pharmaceutical Analysis: Supports drug monitoring and residue studies for firocoxib, which is commonly used in veterinary medicine for pain management in dogs and horses.
• Bioanalytical Method Development and Validation: A key component in developing robust, FDA-compliant analytical methods for regulatory submissions.
• Quality Control in Manufacturing: Can be employed in impurity profiling and stability-indicating assays for firocoxib active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	Firocoxib-D6
CAS No.	1353853-37-8
Molecular Formula	C17H14D6F3N2O4S
Molecular Weight	393.41 g/mol
Synonyms	3-(Cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone-d6; 5,5-Dimethyl-3-(cyclopropylmethoxy)-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone-d6; Firocoxib (hexadeuterated); Firocoxib-d6; Firocoxib Internal Standard; [2H6]-Firocoxib; Deuterated Firocoxib; Previcox-d6 (labeled analog)
EINECS	Contact for details

Quality Control

Our Firocoxib-D6 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and Mass Spectrometry, to confirm identity, isotopic enrichment (typically ≥98 atom % D), and chemical purity (typically ≥95%). Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. Store in a cool, dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.