Description

2-Fluoro-4-Hydroxy-3',5'-Difluoro-4'-(Trifluoromethyl)Biphenyl is a specialized biphenyl derivative featuring multiple fluorine substitutions and a hydroxyl group, making it a valuable fluorinated building block. This compound is critical for applications requiring high chemical stability and specific electronic properties imparted by its unique halogenated structure. It is primarily utilized by researchers and manufacturers in the pharmaceutical and advanced materials sectors for developing novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Acts as a core component or side-chain modifier in the synthesis of fluorinated liquid crystals for high-performance displays.
• Organic Electronics: Employed as a building block for organic semiconductors, OLED materials, and other electronic chemicals due to its electron-withdrawing trifluoromethyl group.
• Polymer Modification: Used to introduce fluorine-containing functional groups into polymer chains to alter surface properties, chemical resistance, and thermal stability.
• Chemical Research: A valuable reagent for academic and industrial R&D in organic synthesis, catalysis, and materials science.

Basic Information

Product Name	2-Fluoro-4-Hydroxy-3',5'-Difluoro-4'-(Trifluoromethyl)Biphenyl
CAS No.	1353578-66-1
Molecular Formula	C₁₃H₆F₆O
Molecular Weight	316.18 g/mol
Synonyms	4'-(Trifluoromethyl)-3',5'-difluoro-2-fluoro-4-hydroxybiphenyl; 2-Fluoro-4-hydroxy-3',5'-difluoro-4'-(trifluoromethyl)-1,1'-biphenyl; 3',5'-Difluoro-2-fluoro-4-hydroxy-4'-(trifluoromethyl)biphenyl; Biphenyl, 2-fluoro-4-hydroxy-3',5'-difluoro-4'-(trifluoromethyl)-; [1,1'-Biphenyl]-4-ol, 2-fluoro-3',5'-difluoro-4'-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Hydroxy-3',5'-Difluoro-4'-(Trifluoromethyl)Biphenyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. We adhere to cGMP standards where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.