Description

Demethylpiperazinyl 7-Desoxo 7-Thioxosildenafil Sulfonic Acid is a high-purity, structurally modified pharmaceutical intermediate derived from the sildenafil family. This compound is critical for advanced research and development in medicinal chemistry, particularly for investigating novel therapeutic pathways and structure-activity relationships. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on developing next-generation active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel PDE-5 inhibitor analogs and related pharmacologically active compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new therapeutic targets and optimize drug efficacy and selectivity.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable synthesis of complex heterocyclic molecules.
• Biochemical Research: Utilized as a tool compound in enzymatic assays and receptor binding studies to understand specific biological mechanisms.

Basic Information

Product Name	Demethylpiperazinyl 7-Desoxo 7-Thioxosildenafil Sulfonic Acid
CAS No.	1353018-10-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	7-Desoxo-7-thioxosildenafil sulfonic acid derivative; Demethylpiperazinyl sildenafil thioanalog; Sildenafil sulfonic acid thioxo analog; PDE-5 inhibitor intermediate 1353018-10-6; 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine 7-thioxo analog; Research compound 1353018-10-6
EINECS	Contact for details

Quality Control

Our Demethylpiperazinyl 7-Desoxo 7-Thioxosildenafil Sulfonic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.