Description

n-Methylated Pomalidomide is a chemically modified derivative of the immunomodulatory drug pomalidomide, designed for advanced pharmaceutical research and development. This compound is valued for its potential to modulate the cereblon E3 ubiquitin ligase complex, offering a critical tool for studying targeted protein degradation and novel therapeutic pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of next-generation treatments for oncology and autoimmune disorders.

Application

• Pharmaceutical R&D: Serves as a key intermediate or reference standard in the development of novel immunomodulatory and anticancer agents.
• PROTAC Development: Used as a ligand or warhead in the design of Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation studies.
• Mechanistic Studies: Employed in biochemical and cellular assays to investigate cereblon-dependent signaling pathways and immune modulation.
• Process Chemistry: Acts as a building block for the synthesis of more complex molecular entities in medicinal chemistry programs.
• Analytical Reference: Provides a high-purity standard for quality control and method development in analytical laboratories (HPLC, LC-MS).

Basic Information

Product Name	n-Methylated Pomalidomide
CAS No.	1352827-50-9
Molecular Formula	C14H11N3O4
Molecular Weight	285.26 g/mol
Synonyms	N-Methylpomalidomide; 4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione N-methyl derivative; CC-4047 N-methyl analog; 3-(4-Amino-1-methyl-2,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)piperidine-2,6-dione; Actimid derivative; Pomalidomide N-methyl analog
EINECS	Contact for details

Quality Control

Our n-Methylated Pomalidomide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.