Description

Fmoc-Peg3-Nhs Ester CAS NO 1352827-47-4 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and an acid-labile Fmoc-protected amine. This compound is a critical reagent for the controlled synthesis of peptide conjugates, bioconjugates, and complex molecular architectures, enabling precise spacing and solubility enhancement. It is primarily utilized by researchers and process developers in the pharmaceutical, biotechnology, and advanced materials sectors for drug delivery system development, protein modification, and linker chemistry.

Application

• Peptide-Polymer Conjugation: Acts as a versatile linker for attaching peptides, proteins, or antibodies to PEG polymers or other macromolecules to improve pharmacokinetics and solubility.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a building block for introducing a hydrophilic, flexible PEG spacer with a protected amine handle into peptide sequences during Fmoc-based synthesis.
• Bioconjugation and ADC Development: Facilitates the site-specific attachment of cytotoxic drugs, fluorophores, or other payloads to antibodies or proteins for creating antibody-drug conjugates (ADCs) and diagnostic probes.
• Hydrogel and Biomaterial Fabrication: Used as a crosslinking agent to incorporate bioactive peptides into hydrogels and polymeric scaffolds for tissue engineering and controlled release applications.
• Surface Functionalization: Enables the covalent immobilization of biomolecules onto NHS-reactive surfaces (e.g., biosensor chips, microarray slides, nanoparticles) via the PEG3 spacer arm.
• Prodrug Synthesis: Employed to create cleavable linkages between active pharmaceutical ingredients (APIs) and solubilizing PEG chains, leveraging the Fmoc group for orthogonal protection strategies.

Basic Information

Product Name	Fmoc-Peg3-Nhs Ester
CAS No.	1352827-47-4
Molecular Formula	C30H36N2O9
Molecular Weight	568.62 g/mol
Synonyms	Fmoc-NH-PEG3-NHS Ester; N-(9-Fluorenylmethoxycarbonyl)-3,6,9-trioxaundecanedioic acid 11-(2,5-dioxo-1-pyrrolidinyl) ester; Fmoc-15-amino-4,7,10,13-tetraoxapentadecanoic acid N-succinimidyl ester; Fmoc-PEG3-OSu; Fmoc-Amino-PEG3-NHS Ester; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,6,9-trioxaundecanedioic acid 11-(2,5-dioxo-1-pyrrolidinyl) ester; Fmoc-N-amido-PEG3-NHS
EINECS	Contact for details

Quality Control

Our Fmoc-Peg3-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.