Description

Febuxostat Acyl-β-D-Glucuronide is a major, pharmacologically relevant metabolite of the xanthine oxidase inhibitor febuxostat. This compound is of critical importance for pharmaceutical research and development, particularly in the fields of drug metabolism and pharmacokinetics (DMPK) studies. It serves as a key reference standard for analytical method development, bioanalytical testing, and regulatory submissions. Researchers and quality control laboratories in the pharmaceutical and biotechnology industries require this high-purity metabolite to ensure accurate quantification and understanding of febuxostat's metabolic profile.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for quantitative analysis in drug development and quality control.
• Metabolite Identification & Profiling: Essential for in vitro and in vivo DMPK studies to map the metabolic pathways of febuxostat.
• Bioanalytical Method Development: Used to develop and validate sensitive LC-MS/MS or HPLC-UV methods for plasma, serum, or urine analysis.
• Pharmacokinetic & Toxicokinetic Studies: Critical for measuring systemic exposure to the acyl glucuronide metabolite, informing safety and efficacy assessments.
• Impurity Characterization: Acts as a marker for related substance testing in active pharmaceutical ingredient (API) and finished product specifications.
• Regulatory Compliance & Submission: Supports regulatory filings (e.g., for FDA, EMA) by providing definitive characterization of a significant human metabolite.

Basic Information

Product Name	Febuxostat Acyl-β-D-Glucuronide
CAS No.	1351692-92-6
Molecular Formula	C24H24N2O9S
Molecular Weight	516.52 g/mol
Synonyms	Febuxostat Acyl Glucuronide; Febuxostat Glucuronide; 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid 1-β-D-glucopyranuronosyl ester; Febuxostat Metabolite; TEI-6720 Glucuronide; TMX-67 Glucuronide; Uloric Metabolite; Febuxostat 1-O-β-Acylglucuronide
EINECS	Contact for details

Quality Control

Our Febuxostat Acyl-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing batch-specific results. Our quality commitment ensures the material is suitable for its intended use as a high-grade reference standard in regulated laboratory environments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Under these conditions, the product is stable for at least two years from the date of receipt. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. The compound should be handled in accordance with good laboratory practice.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.