Description

Propargyl-Peg9-Alcohol is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a terminal propargyl group and a hydroxyl group. This compound is a critical building block in bioconjugation and click chemistry, enabling the precise, covalent attachment of molecules under mild, aqueous conditions. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, functionalized linkers for drug delivery systems, diagnostic probes, and surface modification.

Application

• Bioconjugation and Click Chemistry: Acts as a versatile linker for coupling azide-containing molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for antibody-drug conjugates (ADCs), peptide labeling, and protein modification.
• PEGylation Reagent: Used to introduce hydrophilic PEG spacers onto drugs, proteins, or nanoparticles to improve solubility, reduce immunogenicity, and enhance circulation time in vivo.
• Polymer and Materials Science: Serves as a functional monomer or cross-linker in the synthesis of smart hydrogels, responsive polymers, and biocompatible coatings.
• Diagnostic Probe Development: Facilitates the creation of fluorescent or radioactive probes for imaging and biosensing applications by providing a stable, functional handle for tag attachment.
• Surface Functionalization: Enables the modification of nanoparticles, quantum dots, and solid supports (e.g., glass, gold) with hydroxyl groups for further chemical derivatization.
• Pharmaceutical Intermediates: A key synthetic intermediate in the production of complex active pharmaceutical ingredients (APIs) and prodrugs requiring site-specific PEG attachment.

Basic Information

Product Name	Propargyl-Peg9-Alcohol
CAS No.	1351556-81-4
Molecular Formula	C₂₂H₄₂O₁₀
Molecular Weight	466.57 g/mol
Synonyms	Propargyl-PEG9-OH; 2,5,8,11,14,17,20,23,26-Nonaoxaoctacos-27-yn-1-ol; α-Propargyl-ω-hydroxy-nonaethylene glycol; Propargyl-PEG9-alcohol; Propargyl terminated PEG9 alcohol; 27-Hydroxy-3,6,9,12,15,18,21,24,27-nonaoxa-29-yn-nonacosane; Propargyl-PEG 450 alcohol; 1-Propargylheptaethylene glycol monoether
EINECS	Contact for details

Quality Control

Our Propargyl-Peg9-Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring a reliable supply for research and commercial-scale applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) to prevent oxidation and moisture uptake. Allow the sealed container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Molecular Weight (GPC)	450 - 490 g/mol
Propargyl Group Content (NMR)	≥ 90% of theory

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.