Description

4-(n-Boc-Aminomethyl)-3-Fluorobenzeneboronic Acid Pinacol Ester is a high-value, protected boronic acid ester building block designed for advanced organic synthesis. This compound matters because it provides a versatile handle for Suzuki-Miyaura cross-coupling reactions while its Boc-protected aminomethyl and fluorine substituents offer orthogonal sites for further functionalization, enabling the construction of complex molecular architectures. It is primarily needed by medicinal chemistry and process R&D teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients. CAS No. 1351501-44-4.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and protease inhibitor programs.
• Agrochemical Research: Used to construct novel fluorinated scaffolds for crop protection agents, leveraging the metabolic stability imparted by the fluorine atom.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boronic ester component for forming biaryl and heterobiaryl bonds in complex molecule assembly.
• Peptidomimetic Synthesis: The Boc-protected aminomethyl group allows for the incorporation of this aromatic fragment into peptide-like structures.
• Material Science Precursor: Potential use in creating functionalized organic materials and ligands for catalysis.
• Chemical Biology Probes: Useful for synthesizing tagged or labeled molecules for target identification and binding studies.

Basic Information

Item	Detail
Product Name	4-(n-Boc-Aminomethyl)-3-Fluorobenzeneboronic Acid Pinacol Ester
CAS No.	1351501-44-4
Molecular Formula	C18H27BFNO4
Molecular Weight	351.23 g/mol
Synonyms	[4-[[(1,1-Dimethylethoxy)carbonyl]amino]methyl]-3-fluorobenzeneboronic Acid Pinacol Ester; 3-Fluoro-4-((tert-butoxycarbonylamino)methyl)phenylboronic Acid Pinacol Ester; 4-(Boc-Aminomethyl)-3-Fluorophenylboronic Acid Pinacol Ester; N-Boc-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluorobenzylamine; 2-Fluoro-4-((((tert-butoxycarbonyl)amino)methyl)phenyl)boronic Acid Pinacol Ester; Boc-4-(Pinacolboron)-2-fluorobenzylamine; 1351501-44-4
EINECS	Contact for details

Quality Control

Our 4-(n-Boc-Aminomethyl)-3-Fluorobenzeneboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and hydrolysis. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.