Description

3-Fluoro-4-(Methylthio)Phenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern pharmaceutical and advanced materials research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing fluorinated and sulfur-containing bioactive molecules, including potential drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the unique fluorine and methylthio substituents can enhance biological activity and metabolic stability.
• Material Science: Serves as a monomer or precursor in the synthesis of advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a stable, air-handleable boronic ester partner in palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl bonds.
• Chemical Biology & Probe Development: Utilized in creating molecular probes and labeled compounds for studying biological mechanisms and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated aryl boronic esters.

Basic Information

Product Name	3-Fluoro-4-(Methylthio)Phenylboronic Acid Pinacol Ester
CAS No.	1351499-74-5
Molecular Formula	C₁₃H₁₈BFO₂S
Molecular Weight	268.16 g/mol
Synonyms	[4-(Methylthio)-3-fluorophenyl]boronic acid pinacol ester; 3-Fluoro-4-methylsulfanylbenzeneboronic acid pinacol ester; Pinacol [3-fluoro-4-(methylthio)phenyl]boronate; (3-Fluoro-4-(methylthio)phenyl)boronic acid pinacol ester; B-[3-Fluoro-4-(methylthio)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-[3-fluoro-4-(methylthio)phenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(Methylthio)Phenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems support development from research to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use or when dispensing from the original container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.