Description

Bis-Propargyl-Peg11 CAS NO 1351373-49-3 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring terminal propargyl groups. This compound is a critical building block in advanced bioconjugation and click chemistry applications, enabling the precise, covalent attachment of biomolecules, polymers, and nanoparticles. It is essential for researchers and manufacturers in the pharmaceutical, diagnostics, and advanced materials sectors who require reliable, functionalized linkers for drug delivery systems, surface modification, and hydrogel synthesis.

Application

• Bioconjugation and Click Chemistry: Serves as a versatile linker for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to attach peptides, proteins, or oligonucleotides.
• Drug Delivery System Development: Used to create PEGylated drug conjugates, enhancing solubility, stability, and circulation time of active pharmaceutical ingredients (APIs).
• Surface Functionalization: Enables the modification of nanoparticles, quantum dots, and biosensor surfaces with bio-recognition elements.
• Hydrogel and Polymer Network Formation: Acts as a cross-linking agent for synthesizing biocompatible hydrogels used in tissue engineering and 3D cell culture.
• Diagnostic Reagent Synthesis: A key intermediate in the production of labeled antibodies, antigens, and probes for immunoassays and imaging.
• ADC (Antibody-Drug Conjugate) Linker Chemistry: Facilitates the development of novel, stable linkers for connecting cytotoxic payloads to monoclonal antibodies.

Basic Information

Product Name	Bis-Propargyl-Peg11
CAS No.	1351373-49-3
Molecular Formula	C31H56O13
Molecular Weight	636.8 g/mol
Synonyms	1,1'-[1,11-Bis(2-propyn-1-yloxy)-3,6,9-trioxaundecane-1,11-diyl]bis(2-propyn-1-ol); Propargyl-PEG11-propargyl; α,ω-Bis-propargyl undecaethylene glycol; Bis-Propargyl PEG11; Propargyl-PEG11-Propargyl; 2-Propyn-1-yl 2,5,8,11,14,17,20,23,26,29,32-undecaoxapentatriacont-34-yn-1-yl ether; Heterobifunctional PEG Alkyne Linker
EINECS	Contact for details

Quality Control

Our Bis-Propargyl-Peg11 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FT-IR, to ensure high purity and consistent performance for sensitive research and production applications. Certificates of Analysis (COA) detailing purity, identity, and functional group integrity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.