Description

Bis-Propargyl-Peg10 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring terminal propargyl groups. This compound is engineered for precision conjugation chemistry, enabling the controlled linkage of biomolecules, polymers, and surfaces via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click reactions. It is an essential building block for researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors, where reliable, reproducible linker performance is critical for developing novel therapeutics, diagnostics, and functional polymers.

Application

• Key reagent in click chemistry for bioconjugation and polymer functionalization.
• Synthesis of PEGylated drug conjugates and antibody-drug conjugates (ADCs) to enhance solubility and pharmacokinetics.
• Creation of cross-linked hydrogels and biomaterials for tissue engineering and controlled drug release.
• Surface modification and functionalization of nanoparticles, chips, and other substrates for biosensing applications.
• Production of branched and multi-arm PEG architectures for advanced material science.
• As a versatile spacer or linker molecule in diagnostic assay development and probe synthesis.

Basic Information

Product Name	Bis-Propargyl-Peg10
CAS No.	1351373-47-1
Molecular Formula	C28H50O11
Molecular Weight	562.7 g/mol
Synonyms	α,ω-Bis(2-propynyl)-PEG10; Propargyl-PEG10-propargyl; Bis-propargyl PEG 500; PEG-10 bis(propargyl) ether; 1,1'-[1,11-(3,6,9-Trioxaundecane-1,11-diyl)bis(oxy)]bis(2-propylene); 2,5,8,11,14,17,20,23,26,29-Decaoxahentriacont-30-yne-1,31-diyl bis(2-propynyl) ether; Propargyl-PEG10-Propargyl
EINECS	Contact for details

Quality Control

Our Bis-Propargyl-Peg10 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including NMR, HPLC, and MS, to verify identity, purity, and functional group integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and cGMP-grade production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere (argon or nitrogen), seal the container under vacuum or inert gas after each use to prevent moisture uptake and maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Average Molecular Weight	550 - 580 g/mol
Functional Group Substitution	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.