Description

1-Benzyl-3-Hydroxymethyl-Pyrrolidine-3-Carbonitrile is a versatile pyrrolidine-based nitrile building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring both a benzyl-protected amine and a hydroxymethyl nitrile moiety, makes it a critical intermediate for constructing complex nitrogen-containing heterocycles. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of potential drug candidates, including protease inhibitors, kinase inhibitors, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the pyrrolidine scaffold contributes to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probe Synthesis: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Material Science Research: Investigated as a monomer or building block for specialty polymers and functional materials with unique properties.

Basic Information

Product Name	1-Benzyl-3-Hydroxymethyl-Pyrrolidine-3-Carbonitrile
CAS No.	1350475-49-8
Molecular Formula	C13H16N2O
Molecular Weight	216.28 g/mol
Synonyms	3-(Hydroxymethyl)-1-benzyl-3-pyrrolidinecarbonitrile; 1-Benzyl-3-(hydroxymethyl)pyrrolidine-3-carbonitrile; 3-Cyano-1-benzyl-3-pyrrolidinemethanol; (1-Benzyl-3-pyrrolidinyl)acetonitrile, 3-hydroxy-; Pyrrolidine-3-carbonitrile, 1-benzyl-3-(hydroxymethyl)-
EINECS	Contact for details

Quality Control

Our 1-Benzyl-3-Hydroxymethyl-Pyrrolidine-3-Carbonitrile is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.