Description

(S)-1,1,1,4,4,4-Hexafluoro-2-Butylamine is a high-value, chiral fluorinated amine building block. This compound matters for its role in introducing fluorine atoms and a specific stereocenter into complex molecules, which is critical for modulating their biological activity and physicochemical properties. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and metabolic disease research.
• Agrochemical Synthesis: Used in creating novel, potent herbicides, insecticides, and fungicides where the fluorine moiety enhances stability and bioavailability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Catalyst & Ligand Development: Employed in the design of novel chiral catalysts and ligands for asymmetric synthesis in fine chemical manufacturing.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty fluoropolymers with unique surface properties and chemical resistance.
• Positron Emission Tomography (PET) Tracer Precursor: Potential use in synthesizing fluorine-18 labeled tracers for medical imaging.

Basic Information

Product Name	(S)-1,1,1,4,4,4-Hexafluoro-2-Butylamine
CAS No.	1349699-79-1
Molecular Formula	C4H5F6N
Molecular Weight	181.08 g/mol
Synonyms	(S)-1,1,1,4,4,4-Hexafluoro-2-aminobutane; (S)-1,1,1,4,4,4-Hexafluorobutan-2-amine; (S)-Hexafluoro-sec-butylamine; (S)-2-Amino-1,1,1,4,4,4-hexafluorobutane; (S)-α-Methyl-3,3,3-trifluoropropylamine; (S)-HFA; (S)-1,1,1-Trifluoro-3-(trifluoromethyl)propylamine; (S)-Configuration of 1,1,1,4,4,4-Hexafluoro-2-Butylamine
EINECS	Contact for details

Quality Control

Our (S)-1,1,1,4,4,4-Hexafluoro-2-Butylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.